I have played 3 Civilization Beyond Earth games before this one.
In each playthru, I focused on one of the affinities; Harmony, Purity and Supremacy.
All three games were played on the Mercury difficulty, which is the one where neither the player or the AIs get any bonuses.
The two first I won by my favourite victory condition; domination. The last one, I won by Emancipation.
For this game, I will crank up the difficulty a notch to "Vostock".